Although college enrollment has increased for under-represented minorities, retention and graduation rates continue to lag behind non-minority peers. This study investigates the applicability of empirically validated retention predictors to Native American (i.e., American Indian/Alaskan Native) college student retention. Self-reported data collection began in week four of the fall semester from first time, full time freshman. Out of eleven predictors, fall GPA, institutional commitment, homesickness, academic self-efficacy, and social integration predicted whether or not Native American students returned the fall following their freshman year. Unexpectedly, students’ reporting greater social integration and self-efficacy were less likely to return the following fall. Results emphasize the importance of examining cultural influences on college retention.